Long Fiber Formation of Hydroxyapatite/Collagen Nanocomposites through a Self-Organization Mechanism
نویسنده
چکیده
Long fibers of bone-like hydroxyapatite/collagen nanocomposites were fabricated via a self-organization under biomimetic conditions in order to obtain much more suitable biomechanical and biochemical properties for artificial bone and tissue engineering scaffolds. The fiber growth was controlled with ionic strength in the reaction vessel and was explained by a crystal growth model. The composite fiber grew up to 75 mm in length and demonstrated straight extinction under a polarized microscope. The composite compacts were incorporated into bone metabolism, and their resorption was controlled with crosslinkage. The composite is utilizable for the bone reconstruction materials that can gradually change into bone.
منابع مشابه
Porous Materials of Hydroxyapatite/biopolymers Nanocomposites through Self-organization
With the advent of new treatment of tissue repairs, tissue engineering is one of the key technologies. There are three important factors; scaffold, mechanical stimulation and biochemical factor. In this study, we have developed porous materials of hydroxyapatite, polysaccharides and collagens nanocomposites as a novel scaffold in which the nanostructures were controlled through self-organizatio...
متن کاملDevelopment and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers
Various kinds of three-dimensional (3D) scaffolds have been designed to mimic the biological spontaneous bone formation characteristics by providing a suitable microenvironment for osteogenesis. In view of this, a natural bone-liked composite scaffold, which was combined with inorganic (hydroxyapatite, Hap) and organic (type I collagen, Col) phases, has been developed through a self-assembly pr...
متن کاملHydroxyapatite/collagen bone-like nanocomposite.
Our group has succeeded to synthesize material with bone-like nanostructure and bone-like inorganic and organic composition via self-organization mechanism between them using simultaneous titration method under controlled pH and temperature. The hydroxyapatite/collagen (HAp/Col) bone-like nanocomposite completely incorporated into bone remodeling process to be substituted by new bone. Cells cul...
متن کاملOrder versus Disorder: in vivo bone formation within osteoconductive scaffolds
In modern biomaterial design the generation of an environment mimicking some of the extracellular matrix features is envisaged to support molecular cross-talk between cells and scaffolds during tissue formation/remodeling. In bone substitutes chemical biomimesis has been particularly exploited; conversely, the relevance of pre-determined scaffold architecture for regenerated bone outputs is sti...
متن کاملSelf-assembly and mineralization of peptide-amphiphile nanofibers.
We have used the pH-induced self-assembly of a peptide-amphiphile to make a nanostructured fibrous scaffold reminiscent of extracellular matrix. The design of this peptide-amphiphile allows the nanofibers to be reversibly cross-linked to enhance or decrease their structural integrity. After cross-linking, the fibers are able to direct mineralization of hydroxyapatite to form a composite materia...
متن کامل